BDBM246600 DNA topoisomerase inhibitor, 2

SMILES O=C(NNC(=S)NC(=O)c1ccccc1)c1cc2ccccc2[nH]1

InChI Key InChIKey=IASBQNIEVYMTDQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 246600   

TargetTopoisomerase IV(Staphylococcus aureus)
Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 246600BDBM246600(DNA topoisomerase inhibitor, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetDNA topoisomerase 2-alpha(Human)
Medical University

LigandChemical structure of BindingDB Monomer ID 246600BDBM246600(DNA topoisomerase inhibitor, 2)
Affinity DataIC50: 5.00E+4nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 246600BDBM246600(DNA topoisomerase inhibitor, 2)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of 17beta-HSD2 in human using MDA-MB-231 cells using [3H]-E2 as substrate after 6 hrs by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetDNA topoisomerase 1(Human)
Medical University

LigandChemical structure of BindingDB Monomer ID 246600BDBM246600(DNA topoisomerase inhibitor, 2)
Affinity DataIC50: 1.00E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed