BDBM24689 10-methoxy-DDACTHF, 10R-8::2-({4-[(1R)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl]phenyl}formamido)pentanedioic acid

SMILES CO[C@H](CCCc1c(N)nc(N)[nH]c1=O)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O

InChI Key InChIKey=RUSXEZDHZQNDSF-YSSOQSIOSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24689   

TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
The Scripps Research Institute

LigandPNGBDBM24689(10-methoxy-DDACTHF, 10R-8 | 2-({4-[(1R)-4-(2,4-dia...)
Affinity DataKi:  850nM ΔG°:  -8.30kcal/molepH: 7.5 T: 26°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBifunctional purine biosynthesis protein ATIC(Human)
The Scripps Research Institute

LigandPNGBDBM24689(10-methoxy-DDACTHF, 10R-8 | 2-({4-[(1R)-4-(2,4-dia...)
Affinity DataKi: >1.00E+5nM ΔG°: >-5.47kcal/molepH: 7.4 T: 26°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed