BDBM246948 (5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-methyl-8-pyrimidin-2-yl-5,6-dihydrobis[1,2,4]triazolo[4,3-a:3′,4′-c]pyrazine::US10053463, 105

SMILES C[C@H]1Cn2c(nnc2-c2ncccn2)-c2nnc(-c3cccc(c3Cl)C(F)(F)F)n12

InChI Key InChIKey=ASQFMFPWWORJLB-VIFPVBQESA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 246948   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM246948((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-meth...)
Affinity DataKi:  4nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Mus musculus)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM246948((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-meth...)
Affinity DataKi:  4nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM246948((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-meth...)
Affinity DataIC50:  2nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Mus musculus)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM246948((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-meth...)
Affinity DataIC50:  11.3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent