BDBM246991 1-[2-(Aminomethyl)-2,3-dihydro-1H-inden-2-yl]-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyridin-2(1H)-one::BDBM425203::US10053465, 100::US11136326, Example 100

SMILES NCC1(Cc2ccccc2C1)n1cc(ccc1=O)-c1ncnc2[nH]ccc12

InChI Key InChIKey=MIDUQVCWTKHVHF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 246991   

TargetTyrosine-protein kinase Mer(Human)
Incyte

US Patent
LigandPNGBDBM246991(BDBM425203 | 1-[2-(Aminomethyl)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 500nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Incyte

US Patent
LigandPNGBDBM246991(BDBM425203 | 1-[2-(Aminomethyl)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 500nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Incyte

US Patent
LigandPNGBDBM246991(BDBM425203 | 1-[2-(Aminomethyl)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 500nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
Incyte

US Patent
LigandPNGBDBM246991(BDBM425203 | 1-[2-(Aminomethyl)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 500nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
Incyte

US Patent
LigandPNGBDBM246991(BDBM425203 | 1-[2-(Aminomethyl)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 500nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Incyte

US Patent
LigandPNGBDBM246991(BDBM425203 | 1-[2-(Aminomethyl)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 500nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent