BDBM24717 3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]hexadeca-1(9),2,5,10,12,14-hexaen-5-ylmethanol::Tetrahydropyrazolo[3,4-a]carbazole, 26

SMILES OCc1[nH]nc-2c1CCc1c-2[nH]c2ccccc12

InChI Key InChIKey=YYDWICBIUPSXIV-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24717   

LigandPNGBDBM24717(3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]he...)
Affinity DataEC50:  2.11E+3nMAssay Description:Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Human)
Genentech

LigandPNGBDBM24717(3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]he...)
Affinity DataIC50:  340nMpH: 7.5 T: 22°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed