BDBM247599 US10112931, Example 197::US9434719, 197::US9688672, Example 197

SMILES Cc1nc(C(C)Nc2nccc(N3C(=O)OC[C@@H]3[C@@H](C)O)n2)sc1-c1ccnc(C(C)(C)C(F)(F)F)c1

InChI Key InChIKey=USESWMZOECWBKB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 247599   

LigandChemical structure of BindingDB Monomer ID 247599BDBM247599(US9688672, Example 197 | US9434719, 197 | US101129...)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 247599BDBM247599(US9688672, Example 197 | US9434719, 197 | US101129...)
Affinity DataIC50: 15.9nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 247599BDBM247599(US9688672, Example 197 | US9434719, 197 | US101129...)
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+(NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide pho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 247599BDBM247599(US9688672, Example 197 | US9434719, 197 | US101129...)
Affinity DataIC50: 2.01E+3nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+(NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide pho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2018
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 247599BDBM247599(US9688672, Example 197 | US9434719, 197 | US101129...)
Affinity DataIC50: 2.01E+3nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 247599BDBM247599(US9688672, Example 197 | US9434719, 197 | US101129...)
Affinity DataIC50: 2.01E+3nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent