BDBM247906 US9434719, 138

SMILES CC(Nc1ncc(F)c(N2C(=O)OCC2[C@@H](C)O)n1)c1ncc(-c2cccc(C(F)(F)F)c2)cn1

InChI Key InChIKey=DQWHZZJMALNHIB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 247906   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 247906BDBM247906(US9434719, 138)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 247906BDBM247906(US9434719, 138)
Affinity DataIC50: 24nMpH: 7.4 T: 2°CAssay Description:The biochemical reactions were performed at room temperature in 384-well Greiner flat-bottom plates (Costar, Cat. No. 781201) using a final reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details
US Patent