BDBM249503 US10072016, Compound 101::US10407433, Compound 101::US10913746, Compound 101::US11649240, Compound 101::US9434727, 101::US9777010, Compound 101
SMILES COC(=O)N1Cc2[nH]nc(C(=O)N3CCC(CC3)c3ccc(F)c(F)c3C(F)(F)F)c2C1
InChI Key InChIKey=CTUOVDKHQQRVDA-UHFFFAOYSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 249503
Affinity DataIC50: 7.44nMpH: 7.4 T: 4°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Affinity DataIC50: 14.1nMpH: 7.5 T: 4°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
Affinity DataIC50: 7.44nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Affinity DataIC50: 14.1nMpH: 7.4 T: 25°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Affinity DataIC50: 14.1nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.44nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Affinity DataIC50: 7.44nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Affinity DataIC50: 7.44nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
Affinity DataIC50: 7.44nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair