BDBM249538 US10072016, Compound 136::US10407433, Compound 136::US10913746, Compound 136::US11649240, Compound 136::US9434727, 136::US9777010, Compound 136

SMILES Fc1cc(F)c(c(c1)C1CCN(CC1)C(=O)c1n[nH]c2CN(CCc12)C#N)C(F)(F)F

InChI Key InChIKey=VGWBIQACZZJMGX-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 249538   

TargetTransthyretin(Human)
Columbia University

US Patent
LigandPNGBDBM249538(US9434727, 136 | US10072016, Compound 136 | US9777...)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249538(US9434727, 136 | US10072016, Compound 136 | US9777...)
Affinity DataIC50: 12nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249538(US9434727, 136 | US10072016, Compound 136 | US9777...)
Affinity DataIC50: 12.0nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249538(US9434727, 136 | US10072016, Compound 136 | US9777...)
Affinity DataIC50: 16.7nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249538(US9434727, 136 | US10072016, Compound 136 | US9777...)
Affinity DataIC50: 16.7nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249538(US9434727, 136 | US10072016, Compound 136 | US9777...)
Affinity DataIC50: 16.7nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details
US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249538(US9434727, 136 | US10072016, Compound 136 | US9777...)
Affinity DataIC50: 16.7nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249538(US9434727, 136 | US10072016, Compound 136 | US9777...)
Affinity DataIC50: 16.7nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetRetinol-binding protein 4(Human)
Columbia University

US Patent
LigandPNGBDBM249538(US9434727, 136 | US10072016, Compound 136 | US9777...)
Affinity DataIC50: 16.7nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
US Patent