BDBM250016 US10005782, Compound 138::US9447106, 138::US9556188, Compound 138

SMILES CC1(CCNc2c(C(N)=O)c(nn12)-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C

InChI Key InChIKey=MSJPQXWTZOLGTI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 250016   

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 250016BDBM250016(US9447106, 138 | US9556188, Compound 138 | US10005...)
Affinity DataIC50: 1nMT: 2°CAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 250016BDBM250016(US9447106, 138 | US9556188, Compound 138 | US10005...)
Affinity DataIC50: 1nMAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 250016BDBM250016(US9447106, 138 | US9556188, Compound 138 | US10005...)
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 250016BDBM250016(US9447106, 138 | US9556188, Compound 138 | US10005...)
Affinity DataIC50: 1nMT: 2°CAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
US Patent