BDBM250061 US10005782, Compound 186::US9447106, 186::US9556188, Compound 186

SMILES CCC#CC(=O)N1CCC(CC1)[C@@H]1CCNc2c(C(N)=O)c(nn12)-c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=HHRMZBPOTHWCRJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 250061   

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandPNGBDBM250061(US9447106, 186 | US9556188, Compound 186 | US10005...)
Affinity DataIC50: 1.10nMAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandPNGBDBM250061(US9447106, 186 | US9556188, Compound 186 | US10005...)
Affinity DataIC50: 1.10nMT: 2°CAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandPNGBDBM250061(US9447106, 186 | US9556188, Compound 186 | US10005...)
Affinity DataIC50: 1.10nMT: 2°CAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
US Patent