BDBM250586 US10167273, Example 65::US10544126, Example 65::US11512066, Example 65::US9475795, 65

SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2Cl)(CC1)C#N

InChI Key InChIKey=CQPUJVNWYRAUIJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 250586   

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM250586(US9475795, 65 | US10167273, Example 65 | US1054412...)
Affinity DataIC50: 940nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM250586(US9475795, 65 | US10167273, Example 65 | US1054412...)
Affinity DataIC50: 940nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM250586(US9475795, 65 | US10167273, Example 65 | US1054412...)
Affinity DataIC50: 940nMAssay Description:The ability of a compound to block the intracellular release of calcium mediated by PK1 in RBL2H3 cells expressing human PKR1 receptors is determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM250586(US9475795, 65 | US10167273, Example 65 | US1054412...)
Affinity DataIC50: 940nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent