BDBM25101 6,7-diphenylpteridine-2,4-diamine::CHEMBL48296::diaminopteridine derivative, 24

SMILES Nc1nc(N)c2nc(-c3ccccc3)c(nc2n1)-c1ccccc1

InChI Key InChIKey=DDZJPETYMUJLIW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 25101   Sort by

LigandPNGBDBM25101(CHEMBL48296 | 6,7-diphenylpteridine-2,4-diamine | ...)
Affinity DataIC50: 8.50E+3nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM25101(CHEMBL48296 | 6,7-diphenylpteridine-2,4-diamine | ...)
Affinity DataIC50: 240nMAssay Description:Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM25101(CHEMBL48296 | 6,7-diphenylpteridine-2,4-diamine | ...)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of recombinant human DHFR using dihydrofolate as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed