BDBM25120 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide::BMCL191018 Compound 2::thiophene deriv., 20

SMILES COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2cc1OC

InChI Key InChIKey=JSKUWFIZUALZLX-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 25120   

LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2009
Entry Details Article
PubMed
LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human PLK1 expressed in baculovirus infected in Trichoplusia ni cells using Biotin-Ahx-SFNDTLDFD as substrate in presence of ATP by Top...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Abbott Laboratories

LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataKi:  3.80nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataKi:  4.80nM ΔG°:  -11.2kcal/molepH: 7.5 T: 2°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Abbott Laboratories

LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataKi:  8nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Abbott Laboratories

LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Abbott Laboratories

LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of human PLK3 expressed in baculovirus infected in Trichoplusia ni cells using Biotin-Ahx-SFNDTLDFD as substrate in presence of ATP by Top...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
GlaxoSmithKline R & D

Curated by ChEMBL
LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataIC50: 160nMAssay Description:Inhibition of PDGFR1beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Abbott Laboratories

LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataKi:  163nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
GlaxoSmithKline R & D

Curated by ChEMBL
LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataIC50: 360nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
GlaxoSmithKline R & D

Curated by ChEMBL
LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 11(Human)
GlaxoSmithKline R & D

Curated by ChEMBL
LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
GlaxoSmithKline R & D

Curated by ChEMBL
LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
GlaxoSmithKline R & D

Curated by ChEMBL
LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1/cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
GlaxoSmithKline R & D

Curated by ChEMBL
LigandPNGBDBM25120(BMCL191018 Compound 2 | 5-(5,6-dimethoxy-1H-1,3-be...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed