BDBM25430 4-(2-hydroxyphenyl)-2-(trifluoromethyl)benzonitrile::CHEMBL391548::diarylphenol, 5a

SMILES Oc1ccccc1-c1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=CSOANLOTNWGJSK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 25430   

TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM25430(CHEMBL391548 | 4-(2-hydroxyphenyl)-2-(trifluoromet...)
Affinity DataIC50: 0.0200nMAssay Description:Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM25430(CHEMBL391548 | 4-(2-hydroxyphenyl)-2-(trifluoromet...)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at Androgen receptor in human MDA-kb2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM25430(CHEMBL391548 | 4-(2-hydroxyphenyl)-2-(trifluoromet...)
Affinity DataIC50: 39.9nMAssay Description:Displacement of [3H]DHT from human recombinant AR expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM25430(CHEMBL391548 | 4-(2-hydroxyphenyl)-2-(trifluoromet...)
Affinity DataIC50: 39.9nMpH: 7.4 T: 2°CAssay Description:The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2008
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM25430(CHEMBL391548 | 4-(2-hydroxyphenyl)-2-(trifluoromet...)
Affinity DataIC50: 40nMAssay Description:Binding affinity to human Androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetProgesterone receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM25430(CHEMBL391548 | 4-(2-hydroxyphenyl)-2-(trifluoromet...)
Affinity DataIC50: 4.45E+3nMAssay Description:Binding affinity at human PRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed