BDBM256011 US9481672, 189

SMILES Cn1c2ccc(cc2oc1=O)-n1cc(C(O)=O)c(=O)n([C@@H]2CCc3c2cccc3C(F)(F)F)c1=O

InChI Key InChIKey=JDARDSVOVYVQST-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 256011   

Targetchymase(Golden hamster)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 256011BDBM256011(US9481672, 189)
Affinity DataIC50: 3nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetChymase(Human)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 256011BDBM256011(US9481672, 189)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant chymase using Abz-HPFHL-Lys(Dnp)-NH2 as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetChymase(Canis lupus familiaris)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 256011BDBM256011(US9481672, 189)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant dog chymase using Abz-HPFHL-Lys(Dnp)-NH2 as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCathepsin G(Human)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 256011BDBM256011(US9481672, 189)
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant cathepsin G using DABCYL-Ser-Thr-Leu-Ser-Glu-Lys-Ala-Lys-ProAla-Glu(EDANS) as substrate by fluorescence based analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed