BDBM256570 US10435361, Example 69::US9481648, 69::US9790174, Example 69

SMILES CCOc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCCOC)c4)n3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C

InChI Key InChIKey=PSPWDUMROPJEGG-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 256570   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM256570(US9481648, 69 | US9790174, Example 69 | US10435361...)
Affinity DataIC50: 13nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM256570(US9481648, 69 | US9790174, Example 69 | US10435361...)
Affinity DataIC50: 13nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM256570(US9481648, 69 | US9790174, Example 69 | US10435361...)
Affinity DataIC50: 121nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM256570(US9481648, 69 | US9790174, Example 69 | US10435361...)
Affinity DataIC50: 121nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM256570(US9481648, 69 | US9790174, Example 69 | US10435361...)
Affinity DataIC50: 147nMAssay Description:The following two assay variants can be used for determination of p38 MAPKα inhibition.Method 1The inhibitory activities of test compounds again...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM256570(US9481648, 69 | US9790174, Example 69 | US10435361...)
Affinity DataIC50: 147nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a higher concentration of the p38 MAPKα protein (2.5 uL of 200 ng/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM256570(US9481648, 69 | US9790174, Example 69 | US10435361...)
Affinity DataIC50: 1.53E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM256570(US9481648, 69 | US9790174, Example 69 | US10435361...)
Affinity DataIC50: 1.53E+3nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a shorter period of mixing of the test compound (105 minutes instead of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent