BDBM2566 3-benzyl-4-hydroxy-2H-chromen-2-one::4-hydroxy-coumarin 8::JMC527142 Compound 27

SMILES Oc1c(Cc2ccccc2)c(=O)oc2ccccc12

InChI Key InChIKey=AEIVRFFWQSJCAR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2566   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM2566(3-benzyl-4-hydroxy-2H-chromen-2-one | 4-hydroxy-co...)
Affinity DataIC50:  1.20E+5nMpH: 4.7 T: 37°CAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM2566(3-benzyl-4-hydroxy-2H-chromen-2-one | 4-hydroxy-co...)
Affinity DataIC50:  144nMpH: 7.5Assay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNAD(P)H dehydrogenase [quinone] 1(Human)
University of Manchester

LigandPNGBDBM2566(3-benzyl-4-hydroxy-2H-chromen-2-one | 4-hydroxy-co...)
Affinity DataIC50:  3.20E+3nMpH: 7.5 T: 25°CAssay Description:Recombinant human NQO1 was obtained from Sigma and diluted in 50 mM phosphate buffer to give an absorbance of 0.1 at 550 nm; 5 uL of this solution wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed