BDBM258321 US9493485, 9-162

SMILES C[C@@]1(N=C(N)OC2(CCC2)C1(F)F)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=JJZKNPLOOQSUEC-LJQANCHMSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 258321   

TargetBeta-secretase 1(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258321(US9493485, 9-162)
Affinity DataIC50:  15nMpH: 7.0Assay Description:BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetCathepsin D(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258321(US9493485, 9-162)
Affinity DataIC50: >3.00E+4nMpH: 4.5 T: 37°CAssay Description:Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetBeta-secretase 1(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258321(US9493485, 9-162)
Affinity DataIC50:  40nMpH: 4.5 T: 37°CAssay Description:Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent