BDBM258593 US9493490, 6-(4-(aminomethyl)-2-chlorophenoxy)-7-chlorobenzo[c][1,2]oxaborol-1(3H)-ol::US9493490, B::US9493490, Example 2

SMILES NCc1ccc(Oc2ccc3COB(O)c3c2Cl)c(Cl)c1

InChI Key InChIKey=VGXUHSXKJLKRBG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 258593   

TargetGlutathione S-transferase P/Rho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258593(US9493490, 6-(4-(aminomethyl)-2-chlorophenoxy)-7-c...)
Affinity DataIC50:  2.30E+4nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutathione S-transferase P/Rho-associated protein kinase 2 [5-554](Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258593(US9493490, 6-(4-(aminomethyl)-2-chlorophenoxy)-7-c...)
Affinity DataIC50:  1.60E+4nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutathione S-transferase P/Rho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258593(US9493490, 6-(4-(aminomethyl)-2-chlorophenoxy)-7-c...)
Affinity DataIC50:  1.10E+4nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent