BDBM258595 US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-methylbenzo[c][1,2]oxaborol-1(3H)-ol::US9493490, D::US9493490, Example 4
SMILES Cc1c2B(O)OCc2ccc1Oc1ccc(CN)cc1F
InChI Key InChIKey=ZCITXZXBLWIHHP-UHFFFAOYSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 258595
TargetGlutathione S-transferase P/Rho-associated protein kinase 1 [1-535](Human)
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 340nMT: 25°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
TargetGlutathione S-transferase P/Rho-associated protein kinase 2 [5-554](Human)
Anacor Pharmaceuticals
US Patent
Anacor Pharmaceuticals
US Patent
Affinity DataIC50: 250nMT: 25°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Affinity DataIC50: 9.25nMT: 25°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Affinity DataIC50: >20nMT: 25°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of GST-tagged ROCK2 (5 to 554 residues) (unknown origin) using S6-peptide as substrate preincubated for 15 mins followed by 33P-ATP additi...More data for this Ligand-Target Pair
Affinity DataIC50: >20nMT: 25°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Affinity DataIC50: 5.01nMT: 25°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of GST-tagged ROCK1 (1 to 535 residues) (unknown origin) using S6-peptide as substrate preincubated for 15 mins followed by 33P-ATP additi...More data for this Ligand-Target Pair
Affinity DataIC50: 4.06nMT: 25°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair