BDBM258951 US9499502, 9ba
SMILES C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(NC(=O)c2ncc(F)cc2F)cc(F)c1F
InChI Key InChIKey=TYKNJIJSJJKNDB-IBGZPJMESA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 258951
Affinity DataKi: 1nM ΔG°: -12.5kcal/molepH: 5.0 T: 30°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN...More data for this Ligand-Target Pair
Affinity DataKi: 21nM ΔG°: -10.6kcal/molepH: 5.0 T: 30°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair