BDBM259272 US9499547, 13

SMILES C[C@H](CN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key InChIKey=CMDIADSAZCFCCT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 259272   

LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50: 34nMpH: 7.5 T: 2°CAssay Description:MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant MNK1 by measuring phosphorylation of biotinylated peptide TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50: 40nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant MNK1 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50: 904nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50: 904nMAssay Description:Inhibition of human recombinant MNK2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM259272(US9499547, 13)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MNK1 in human A549 cells assessed as downregulation of eIF4E phosphorylation level incubated for 2 hrs by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed