BDBM259428 US10457647, Example 27::US11180460, Example 27::US11673868, Example 27::US9512084, 27

SMILES CO[C@@H]1C[C@@H](COc2c(N)ncnc2-c2cc(F)cc(NC(=O)c3ccc(cc3F)C3CC3)c2C)N(C1)C(=O)C#CC

InChI Key InChIKey=QJICETNTYGZLMO-FCHUYYIVSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 259428   

TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259428(US10457647, Example 27 | US11180460, Example 27 | ...)
Affinity DataIC50:  3nMpH: 7.5 T: 30°CAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259428(US10457647, Example 27 | US11180460, Example 27 | ...)
Affinity DataIC50:  3nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259428(US10457647, Example 27 | US11180460, Example 27 | ...)
Affinity DataIC50:  3nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase BTK(Human)
Novartis

US Patent
LigandPNGBDBM259428(US10457647, Example 27 | US11180460, Example 27 | ...)
Affinity DataIC50:  3nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent