BDBM259881 US10308662, Compound 122::US9505780, 122

SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(c2)-c2csc3c2oc(cc3=O)N2CCOCC2)no1

InChI Key InChIKey=UXPIXIQCBOEZLL-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 259881   

LigandPNGBDBM259881(US9505780, 122 | US10308662, Compound 122)
Affinity DataIC50: 950nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259881(US9505780, 122 | US10308662, Compound 122)
Affinity DataIC50: 950nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM259881(US9505780, 122 | US10308662, Compound 122)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM259881(US9505780, 122 | US10308662, Compound 122)
Affinity DataIC50: 1.35E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259881(US9505780, 122 | US10308662, Compound 122)
Affinity DataIC50: 2.57E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [44-167](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259881(US9505780, 122 | US10308662, Compound 122)
Affinity DataIC50: 2.57E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259881(US9505780, 122 | US10308662, Compound 122)
Affinity DataIC50: 4.88E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259881(US9505780, 122 | US10308662, Compound 122)
Affinity DataIC50: 4.88E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM259881(US9505780, 122 | US10308662, Compound 122)
Affinity DataIC50: 8.65E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

LigandPNGBDBM259881(US9505780, 122 | US10308662, Compound 122)
Affinity DataIC50: 8.65E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent