BDBM260469 US10428074, Example 34::US9527851, 34::US9527851, example 34

SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1

InChI Key InChIKey=DNBCBAXDWNDRNO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 260469   

TargetTyrosine-protein kinase JAK1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260469(US9527851, 34 | US9527851, example 34 | US10428074...)
Affinity DataIC50: 2nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260469(US9527851, 34 | US9527851, example 34 | US10428074...)
Affinity DataIC50: 2nMpH: 7.3 T: 2°CAssay Description:TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260469(US9527851, 34 | US9527851, example 34 | US10428074...)
Affinity DataIC50: 2nMAssay Description:JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260469(US9527851, 34 | US9527851, example 34 | US10428074...)
Affinity DataIC50: 5nMAssay Description:JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260469(US9527851, 34 | US9527851, example 34 | US10428074...)
Affinity DataIC50: 5nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260469(US9527851, 34 | US9527851, example 34 | US10428074...)
Affinity DataIC50: 5nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent