BDBM262613 4-((3,3-difluoropiperidin-4-yl)methyl)-4′-(piperidin-4- yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 465

SMILES NS(=O)(=O)c1c(CC2CCNCC2(F)F)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1

InChI Key InChIKey=NCABSMXIAOPVCM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 262613   

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 262613BDBM262613(4-((3,3-difluoropiperidin-4-yl)methyl)-4′-(p...)
Affinity DataIC50: 1.64nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 262613BDBM262613(4-((3,3-difluoropiperidin-4-yl)methyl)-4′-(p...)
Affinity DataIC50: 2.70nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 262613BDBM262613(4-((3,3-difluoropiperidin-4-yl)methyl)-4′-(p...)
Affinity DataIC50: 3.31nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent