BDBM263214 2,5-dimethyl-1-[4-(4-methyl-pyrazol-1-ylmethyl)-benzyl]-1h-pyrrole-3-carboxylic acid (1-amino-isoquinolin-6-ylmethyl)-amide::US9533987, example 9

SMILES Cc1cnn(Cc2ccc(Cn3c(C)cc(C(=O)NCc4ccc5c(N)nccc5c4)c3C)cc2)c1

InChI Key InChIKey=OUIUBQFLHJFGIC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263214   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263214(US9533987, example 9 | 2,5-dimethyl-1-[4-(4-methyl...)
Affinity DataIC50: 14.3nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263214(US9533987, example 9 | 2,5-dimethyl-1-[4-(4-methyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent