BDBM263240 3-cyclopropyl-1-(5-methoxy-6-pyrrolidin-1-yl-pyridin-3-ylmethyl)-1h-pyrazole-4-carboxylic acid (1-amino-isoquinolin-6-ylmethyl)-amide::US9533987, example 25

SMILES COc1cc(Cn2cc(C(=O)NCc3ccc4c(N)nccc4c3)c(n2)C2CC2)cnc1N1CCCC1

InChI Key InChIKey=CUQLASPMTDPMRH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263240   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263240(US9533987, example 25 | 3-cyclopropyl-1-(5-methoxy...)
Affinity DataIC50: 7.31nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263240(US9533987, example 25 | 3-cyclopropyl-1-(5-methoxy...)
Affinity DataIC50: 2.21E+3nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent