BDBM263306 3-cyclopropyl-1-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-ylmethyl]-1h-pyrazole-4-carboxylic acid (1-amino-isoquinolin-6-ylmethyl)-amide::US9533987, example 87

SMILES Nc1nccc2cc(CNC(=O)c3cn(Cc4ccc(nc4)N4CCC(F)(F)C4)nc3C3CC3)ccc12

InChI Key InChIKey=JPOJBUJCQDGKSB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263306   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263306(US9533987, example 87 | 3-cyclopropyl-1-[6-(3,3-di...)
Affinity DataIC50: 23.2nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263306(US9533987, example 87 | 3-cyclopropyl-1-[6-(3,3-di...)
Affinity DataIC50: 6.46E+3nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent