BDBM263326 3-amino-1-[4-(2-oxo-2h-pyridin-1-ylmethyl)-benzyl]-1h-pyrazole-4-carboxylicacid (1h-indazol-4-ylmethyl)-amide::US9533987, example 113

SMILES Nc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1cccc2[nH]ncc12

InChI Key InChIKey=XAOAFFYPRSRGEH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263326   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263326(US9533987, example 113 | 3-amino-1-[4-(2-oxo-2h-py...)
Affinity DataIC50: 13.3nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263326(US9533987, example 113 | 3-amino-1-[4-(2-oxo-2h-py...)
Affinity DataIC50: 5.95E+3nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent