BDBM263331 1-[4-(4-methyl-pyrazol-1-ylmethyl)-benzyl]-1h-pyrazole-4-carboxylic acid (4,6-dimethyl-1h-pyrrolo[2,3-b]pyridin-5-ylmethyl)-amide::US9533987, example 118

SMILES Cc1cnn(Cc2ccc(Cn3cc(cn3)C(=O)NCc3c(C)nc4[nH]ccc4c3C)cc2)c1

InChI Key InChIKey=VAMAGHITSPCHFP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263331   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263331(US9533987, example 118 | 1-[4-(4-methyl-pyrazol-1-...)
Affinity DataIC50: 14nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263331(US9533987, example 118 | 1-[4-(4-methyl-pyrazol-1-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent