BDBM263342 1-[4-(2-oxo-2h-pyridin-1-ylmethyl)-benzyl]-3-trifluoromethyl-1h-pyrazole-4-carboxylic acid (5-chloro-1h-indazol-3-ylmethyl)-amide::US9533987, example 129

SMILES FC(F)(F)c1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1n[nH]c2ccc(Cl)cc12

InChI Key InChIKey=LQMUSHCKCADHQE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263342   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263342(US9533987, example 129 | 1-[4-(2-oxo-2h-pyridin-1-...)
Affinity DataIC50: 2.14nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263342(US9533987, example 129 | 1-[4-(2-oxo-2h-pyridin-1-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent