BDBM263694 6-(2,3- dimethyl- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy_ phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 31

SMILES Cc1cccc(c1C)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1

InChI Key InChIKey=GTNPDWWRBANDGJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 263694   

TargetEstrogen receptor(Human)
Sanofi

US Patent
LigandPNGBDBM263694(6-(2,3- dimethyl- phenyl)-5-[4- [(3S)-1-(3- fluoro...)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetEstrogen receptor [Y537S](Human)
Sanofi

US Patent
LigandPNGBDBM263694(6-(2,3- dimethyl- phenyl)-5-[4- [(3S)-1-(3- fluoro...)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetEstrogen receptor [D538G](Human)
Sanofi

US Patent
LigandPNGBDBM263694(6-(2,3- dimethyl- phenyl)-5-[4- [(3S)-1-(3- fluoro...)
Affinity DataIC50: 19nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent