BDBM26507 N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide::sultam hydroxyethylamine (HEA) derivative, 9c

SMILES CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC(C)(C)CCCC(C)C)N1CCCCS1(=O)=O

InChI Key InChIKey=HTVIBPYYVYUSBD-XZWHSSHBSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26507   

TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26507(N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hy...)
Affinity DataIC50:  30nMpH: 4.5 T: 22°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26507(N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hy...)
Affinity DataIC50:  5.25E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26507(N-[(2S,3R)-4-[(2,6-dimethylheptan-2-yl)amino]-3-hy...)
Affinity DataIC50:  7.94E+3nMpH: 4.5 T: 22°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed