BDBM26543 (3R)-1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}pyrrolidine-3-thiol::BMCL1844 Compound 2::thiol-arylsulfonamide, 4b
SMILES CC#CCOc1ccc(cc1)S(=O)(=O)N1CC[C@@H](S)C1
InChI Key InChIKey=BLIQFUCBRCDFAI-CYBMUJFWSA-N
Data 12 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 26543
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Human)
Vertex Pharmaceuticals
Vertex Pharmaceuticals
Affinity DataKi: 28nM ΔG°: -10.2kcal/molepH: 7.5 T: 22°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Human)
Vertex Pharmaceuticals
Vertex Pharmaceuticals
Affinity DataKi: 28nM ΔG°: -10.2kcal/molepH: 7.5 T: 22°CAssay Description:The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep...More data for this Ligand-Target Pair
Affinity DataKi: 200nM ΔG°: -9.04kcal/molepH: 7.4 T: 22°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 200nM ΔG°: -9.04kcal/molepH: 7.4 T: 22°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nM ΔG°: -7.99kcal/molepH: 7.4 T: 22°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nM ΔG°: -7.99kcal/molepH: 7.4 T: 22°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 1.90E+3nM ΔG°: -7.72kcal/molepH: 7.4 T: 22°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 1.90E+3nM ΔG°: -7.72kcal/molepH: 7.4 T: 22°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 5.00E+3nM ΔG°: -7.15kcal/molepH: 7.4 T: 22°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 5.00E+3nM ΔG°: -7.15kcal/molepH: 7.4 T: 22°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: >6.00E+3nM ΔG°: >-7.05kcal/molepH: 7.4 T: 22°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: >6.00E+3nM ΔG°: >-7.05kcal/molepH: 7.4 T: 22°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair