BDBM26571 (3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]methyl}benzene)oxane-3,4-dicarboxamide::imidazopyridine, 45

SMILES ONC(=O)[C@H]1COCC[C@H]1NC(=O)c1ccc(Cc2c(nc3ccccn23)C(F)(F)F)cc1

InChI Key InChIKey=UWFRWYGMHWPIMQ-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26571   

LigandPNGBDBM26571((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)im...)
Affinity DataIC50: 1.5nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Bristol-Myers Squibb

LigandPNGBDBM26571((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)im...)
Affinity DataKi:  3.25E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM26571((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)im...)
Affinity DataKi: >3.33E+3nM ΔG°: >-7.47kcal/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Bristol-Myers Squibb

LigandPNGBDBM26571((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)im...)
Affinity DataKi: >4.50E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Bristol-Myers Squibb

LigandPNGBDBM26571((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)im...)
Affinity DataKi: >6.37E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed