BDBM267219 US10167281, Compound 129::US9718812, 129

SMILES FC(F)c1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCOCC1

InChI Key InChIKey=WMJGQOFBEIMECG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 267219   

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267219(US10167281, Compound 129 | US9718812, 129)
Affinity DataIC50:  32nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267219(US10167281, Compound 129 | US9718812, 129)
Affinity DataIC50:  27nMAssay Description:YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267219(US10167281, Compound 129 | US9718812, 129)
Affinity DataIC50:  32nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267219(US10167281, Compound 129 | US9718812, 129)
Affinity DataIC50:  27nMAssay Description:YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent