BDBM267352 3-chloro-5-((1-((6-(difluoromethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile::US10189831, Example 128::US9718819, 128

SMILES FC(F)c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1

InChI Key InChIKey=QQUUMRRVPUBFDC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 267352   

TargetGag-Pol polyprotein(HIV-1)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267352(3-chloro-5-((1-((6-(difluoromethyl)-3-oxo-2,3-dihy...)
Affinity DataIC50: 4nMAssay Description:The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
US Patent

TargetGag-Pol polyprotein(HIV-1)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267352(3-chloro-5-((1-((6-(difluoromethyl)-3-oxo-2,3-dihy...)
Affinity DataIC50: 4nMpH: 7.8 T: 2°CAssay Description:The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2018
Entry Details
US Patent