BDBM269300 (R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-2-(3-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-1H-imidazol-5(4H)-one ::US10413545, Compound 45::US9718813, Compound 45
SMILES Cn1cc(-c2ccc(-c3ccc(C4=NC(C)(C)C(=O)N4C[C@@H]4CCN(C(=O)C5CC5)C4)c(F)c3)cc2)cn1
InChI Key InChIKey=LSPCBIRSCVVDPC-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 269300
Affinity DataIC50: 63.1nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Affinity DataIC50: 63.1nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Affinity DataIC50: 112nMpH: 7.5 T: 2°CAssay Description:10 μL assay buffer (100 mM KH2PO4 pH 7.5) was added to a 384-well clear plate (costar 3702). 0.3 μL compound (at concentrations of 30 μ...More data for this Ligand-Target Pair