BDBM269343 (R)-2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)-1-((1-(1-hydroxycyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-4,4-dimethyl-1H-imidazol-5(4H)-one ::US10413545, Compound 88::US9718813, Compound 88

SMILES CC1(C)N=C(c2ccc(-c3ccc4cc(F)ccc4c3)cc2F)N(C[C@@H]2CCN(C(=O)C3(O)CC3)C2)C1=O

InChI Key InChIKey=CNCVLLYPFZPUDC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 269343   

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 269343BDBM269343((R)-2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)...)
Affinity DataIC50: 20.4nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 269343BDBM269343((R)-2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)...)
Affinity DataIC50: 20.4nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details
US Patent