BDBM269358 (E)-3-(4-((2-(4-fluoro- 2-methylphenyl)-6- hydroxybenzo[b] thiophen-3-yl)oxy) phenyl)-acrylic acid::US10058534, 12

SMILES Cc1cc(F)ccc1-c1sc2cc(O)ccc2c1Oc1ccc(\C=C\C(O)=O)cc1

InChI Key InChIKey=PSVTZBLEFONQPD-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 269358   

TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM269358((E)-3-(4-((2-(4-fluoro- 2-methylphenyl)-6- hydroxy...)
Affinity DataEC50:  4nMAssay Description:Induction of ERalpha degradation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM269358((E)-3-(4-((2-(4-fluoro- 2-methylphenyl)-6- hydroxy...)
Affinity DataIC50: 4nMAssay Description:Induction of selective estrogen receptor alpha degradation in human MCF7 cells after 18 to 24 hrs by in-cell Western analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM269358((E)-3-(4-((2-(4-fluoro- 2-methylphenyl)-6- hydroxy...)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:Plate MCF7 cells at 0.3 million cells/mL (100 l/well) in black, clear-bottom 96-well plates (Greiner, catalog number 655090) in DMEM/F12 media (Gibco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM269358((E)-3-(4-((2-(4-fluoro- 2-methylphenyl)-6- hydroxy...)
Affinity DataIC50: 78nMAssay Description:Induction of selective estrogen receptor alpha degradation in human MCF7 cells harboring TK-ERE-Luc assessed as reduction in estradiol-induced transc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM269358((E)-3-(4-((2-(4-fluoro- 2-methylphenyl)-6- hydroxy...)
Affinity DataIC50: 78nMpH: 5.1 T: 2°CAssay Description:The ER transcription assay is a reporter assay that is based on the ability of ER to induce transcription from a luciferase reporter gene containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent