BDBM269455 (E)-3-(4-((2-(4-fluoro- 2-isopropylphenyl)-6- hydroxybenzo[b] thiophen-3- yl)oxy)phenyl)acrylic acid::US10058534, 110

SMILES CC(C)c1cc(F)ccc1-c1sc2cc(O)ccc2c1Oc1ccc(\C=C\C(O)=O)cc1

InChI Key InChIKey=LUBHQZQOZZEIFB-LFYBBSHMSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 269455   

TargetEstrogen receptor(Human)
Novartis

US Patent
LigandPNGBDBM269455((E)-3-(4-((2-(4-fluoro- 2-isopropylphenyl)-6- hydr...)
Affinity DataIC50:  0.5nMpH: 7.4 T: 25°CAssay Description:Plate MCF7 cells at 0.3 million cells/mL (100 l/well) in black, clear-bottom 96-well plates (Greiner, catalog number 655090) in DMEM/F12 media (Gibco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetEstrogen receptor(Human)
Novartis

US Patent
LigandPNGBDBM269455((E)-3-(4-((2-(4-fluoro- 2-isopropylphenyl)-6- hydr...)
Affinity DataIC50:  24nMpH: 5.1 T: 37°CAssay Description:The ER transcription assay is a reporter assay that is based on the ability of ER to induce transcription from a luciferase reporter gene containing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent