BDBM269490 (S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,3,4,5-tetrahydropyridin-2-yl)-4-fluoro-phenyl)-5-cyanopicolinamide ::US10058540, 6

SMILES NC1=N[C@](CF)(c2cc(NC(=O)c3ccc(cn3)C#N)ccc2F)C(F)(F)CC1

InChI Key InChIKey=MKGIGVAZBLMJAS-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 269490   

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM269490((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  20nM ΔG°:  -10.5kcal/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent