BDBM270312 US10059667, Example 33

SMILES C[C@@H]([C@@H](C1CC1)c1cccc(OC[C@H]2CCN(Cc3cc(ccc3C(F)(F)F)C(F)(F)F)C2)c1)C(O)=O

InChI Key InChIKey=ZWEPLVRKODLNSK-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 270312   

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270312(US10059667, Example 33)
Affinity DataEC50:  5.30nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270312(US10059667, Example 33)
Affinity DataEC50:  158nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent