BDBM270326 US10059667, Example 47

SMILES OC(=O)C[C@@H](C1CC1)c1cccc(OCC2CCN(Cc3cc(ccc3C(F)(F)F)C(F)(F)F)C2)c1

InChI Key InChIKey=DGBCSNDKDZKHCJ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 270326   

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270326(US10059667, Example 47)
Affinity DataEC50:  42nMpH: 7.4 T: 2°CAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM270326(US10059667, Example 47)
Affinity DataEC50:  560nMT: 2°CAssay Description:The assay was performed in 96-well format. HEK cells stably expressing human GPR40 were plated to be 60-80% confluent within 72 h. After 72 h, the pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent