BDBM274256 6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 53

SMILES COc1ncc(-c2cc3C(=O)N(C(c3n2C)c2ccc(Cl)cc2)c2cc(C)c(=O)n(C)c2)c(OC)n1

InChI Key InChIKey=QLRYSHYUZMZZPY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 274256   

TargetBromodomain-containing protein 4 [44-477](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274256(6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)...)
Affinity DataIC50:  40nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274256(6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)...)
Affinity DataIC50:  39nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [60-463](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM274256(6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)...)
Affinity DataIC50:  41nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent