BDBM274453 N-(6-(1-(1-((1,3-dimethyl-1H-pyrazol-4- yl)methyl)piperidin-4-yl)-4-(4- fluorophenyl)-1H-imidazol-5- yl)imidazo[1,2-b]pyridazin-2-yl)-2- fluoroisonicotinamide::US9556179, Compound 22

SMILES O=C(Nc1cn2nc(-c3c(-c4ccc(F)cc4)ncn3C3CCN(Cc4c[nH]cn4)CC3)ccc2n1)c1ccnc(F)c1

InChI Key InChIKey=QWGGHVMXDWYLFW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274453   

TargetCasein kinase I isoform delta(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 274453BDBM274453(N-(6-(1-(1-((1,3-dimethyl-1H-pyrazol-4- yl)methyl)...)
Affinity DataIC50: 0.101nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetCasein kinase I isoform epsilon(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 274453BDBM274453(N-(6-(1-(1-((1,3-dimethyl-1H-pyrazol-4- yl)methyl)...)
Affinity DataIC50: 1.29nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent