BDBM275797 5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)oxy)-2-fluoro- N-(pyrrolidin-1- ylsulfonyl)benzamide::US10071957, Example 14

SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCCC2)cc1Cl

InChI Key InChIKey=ZKEIWRLJUHLQBC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275797   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM275797(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Affinity DataIC50: 30.1nMpH: 7.4 T: 2°CAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM275797(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Affinity DataIC50: 44nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent