BDBM275883 US10071965, Compound PT173
SMILES CCc1ccn(Cc2cccc(N)c2C)c(=O)c1
InChI Key InChIKey=CWLNKRWVJHVVKW-UHFFFAOYSA-N
Data 4 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 275883
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
The Research Foundation For The State University of New York
US Patent
The Research Foundation For The State University of New York
US Patent
Affinity DataKi: 2nM ΔG°: -11.9kcal/molepH: 7.5 T: 25°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
The Research Foundation For The State University of New York
US Patent
The Research Foundation For The State University of New York
US Patent
Affinity DataKi: 7.30nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
The Research Foundation For The State University of New York
US Patent
The Research Foundation For The State University of New York
US Patent
Affinity DataKi: 203nM ΔG°: -9.12kcal/molepH: 7.5 T: 25°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
The Research Foundation For The State University of New York
US Patent
The Research Foundation For The State University of New York
US Patent
Affinity DataKi: 246nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair